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TASP 0277308

CAS No. 945725-50-8

TASP 0277308( —— )

Catalog No. M35256 CAS No. 945725-50-8

TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesisin vivo.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    TASP 0277308
  • Note
    Research use only, not for human use.
  • Brief Description
    TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesisin vivo.
  • Description
    TASP0277308 is a highly selective S1P1 antagonist. TASP0277308 possesses immunomodulatory activities, including lymphopenia, a block in T cell egress from the thymus, marginal zone B cell displacement, and the upregulation of CD69 expression on lymphocytes. TASP0277308 can be used for the research of collagen-induced arthritis in mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    945725-50-8
  • Formula Weight
    539.48
  • Molecular Formula
    C23H28Cl2N6O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O(C=1N(CC)C([C@H](NS(=O)(=O)C2=CC(Cl)=C(Cl)C=C2)C)=NN1)C3=CC(=CC=C3)N4CCN(C)CC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fujii Y, et al. Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities. J Immunol. 2012 Jan 1;188(1):206-15.?
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